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Deep learning cascade networks for segmentation of fluorine-18 sodium fluoride positron emission tomography scans of equine metacarpo- and metatarsophalangeal joints outperform atlas-based method. To create a labeled dataset and evaluate a convolutional neural network (CNN) for segmentation of fluorine-18 sodium fluoride PET scans of the equine metacarpo- and metatarsophalangeal joint (fetlock), targeting the third metacarpal bone, proximal phalanx, proximal sesamoid bone(s), and soft tissue. Unassigned: PET and corresponding CT scans were retrospectively selected from June 2024 through November 2025 using convenience sampling and coregistered to a common reference frame. The coregistered PET-CT scans were manually labeled; the labels were then transferred to PET-only images and used to...
Ertapenem Pharmacokinetics in Equine Plasma and Synovial Fluid Following a Single Intravenous Dose. This study describes the pharmacokinetics of ertapenem, a carbapenem antimicrobial that has not been previously studied in equids. Administered as a 30 mg/kg intravenous bolus to six healthy horses, serial blood and synovial samples were obtained over 8 h after administration. Pharmacokinetic analysis of plasma and synovial fluid was performed. In plasma, the AUC was 353.10 h × μg/mL (CV = 49.02%), Vss 79.34 mL/kg (CV = 22.85%), CL 84.96 mL/h/kg (CV = 31.31%) and t1/2 2.03 h (CV = 15.32%). In synovial fluid, the AUC was 524.10 h × μg/mL (CV = 16.03...
The Effect of Lipemia on Insulin and Adiponectin Measurement in Equine Blood Samples. Lipemia is a common comorbidity in horses with obesity or equine metabolic syndrome, but the impact of lipemia on the measurement of insulin and adiponectin has not been evaluated. Objective: To evaluate endogenous and exogenous lipemic interference with equine insulin and adiponectin measurements via several commercial assays. Methods: Endogenous lipemia was evaluated using plasma and serum samples with triglyceride concentrations of 1000 mg/dL (n = 6 each). Sample insulin concentrations were determined via fluorescence enzyme immunoassay (FEIA), ELISA, and lateral flow assay (LFA). ...
TGF-β1 and estradiol modulate prostaglandin concentrations and related gene expression in equine endometrium during the follicular phase. Transforming growth factor (TGF)-β1 is a pro-fibrotic cytokine that affects extracellular matrix (ECM) deposition and fibroblast activity. 17β-Estradiol (E), the dominant ovarian steroid during the follicular phase (FLP) of the estrous cycle, can also influence ECM remodeling and fibrosis, through prostaglandin (PG) synthesis. PGs have opposing roles in fibrosis, with PGE₂ showing anti-fibrotic effects and PGF₂α promoting fibrosis. Equine endometrosis, whose main pathological feature is fibrosis, is marked by chronic inflammation and ECM accumulation, and may involve mediators like TGF-...
Radiographic findings of candidate stallions presented for licensing at all German Warmblood horse-breeding associations in 2018-2020. Current studies on the health status of young German Warmblood stallions are lacking. Objective: To evaluate the prevalence of radiographic findings at licensing examinations of Warmblood candidate stallions and quantify the environmental influences on the distribution of recorded findings. Methods: In this retrospective observational study, records of 1693 radiographic examinations performed on 1678 German Warmblood stallions presented for licensing in 2018-2020 were reviewed. Data were provided by all German Warmblood horse-breeding associations and their official veterinarians. The collecti...
Markers of bone turnover, parathyroid hormone, calcium, and magnesium concentrations in horses with acute colitis. Hypocalcemia is frequent in horses with colitis. Information on serum parathyroid hormone (PTH) concentrations and its association with bone turnover biomarkers in horses with colitis is lacking. We aimed to determine the association between serum bone resorption biomarkers (C-terminal telopeptide of type I collagen [CTX-I]) and bone formation (osteocalcin [OCN]) with blood PTH, total calcium (tCa), ionized calcium (iCa), phosphorus (Pi), and total magnesium (tMg) concentrations, and mortality in horses with acute colitis. A total of 163 horses were divided into colitis (n = 127) and healt...
Characterization of the Endometrial Microbiota of Healthy Mares Across the Estrous Cycle. In the past, bacteria detected in the mare's uterus were generally interpreted as a sign of endometritis, since the uterus was considered a sterile environment. This assumption has been challenged by the introduction of culture-independent molecular techniques, particularly 16S rRNA amplicon sequencing, which have demonstrated that healthy mares harbor an endometrial microbiota. The aim of this study was to characterize the endometrial microbiota of healthy mares and to determine whether microbial composition differs between estrus and diestrus. Endometrial samples were collected from eleven h...
Effects of L-selenomethionine supplementation on nutrient digestibility and metabolism, antioxidant capacity, hormone levels, and fecal microbiota diversity in pregnant Yili mares during mid- to late gestation. L-selenomethionine (L-SeMet), a highly bioavailable organic form of selenium, plays a critical role in maintaining antioxidant homeostasis, regulating reproductive hormone secretion, and improving intestinal microbial ecology. Previous studies have demonstrated that appropriate supplementation with L-SeMet can significantly enhance the production performance and health status of ruminants. However, the nutritional regulatory mechanisms and physiological effects of L-SeMet in monogastric herbivores, particularly horses during mid- to late gestation, remain inadequately understood. Therefore, th...
[Equine laryngeal dysplasia – overview of variable clinical presentation based on 6 cases]. Equine laryngeal dysplasia (ELD) is the umbrella term for various malformations of laryngeal structures that arise from the 4th and 6th branchial arches during embryogenesis. The disease is rare and may be subclinical. In symptomatic patients with clinical signs, the clinical presentation is highly variable and is the result of functional limitations of the larynx as well as of the esophageal sphincter. The spectrum of signs may range from respiratory changes such as abnormal respiratory noise, coughing, and at times dyspnea all the way to poor performance, dysphagia, aerophagia, and colic. Th...
The majority of proximal sesamoid and condylar fractures occurred in horses identified as high risk by inertial measurement unit sensors. To determine whether targeted lesion-specific algorithms developed from data collected with accelerometer-based inertial measurement units worn by racing Thoroughbreds could retrospectively identify horses at high risk of incurring forelimb condylar or proximal sesamoid fractures. Unassigned: Fracture-specific algorithms were generated from July 2021 to December 2024 with accelerometer data from 42,623 races by 15,755 horses, including 54 races by 23 horses that subsequently suffered condylar fractures and 90 races by 31 horses that later sustained proximal sesamoid fractures. Fracture-specifi...
Standing superficial keratectomy provides long-term control of epithelial and stromal equine immune-mediated keratitis. To describe the demographics and treatment outcomes of horses definitively diagnosed with epithelial or stromal immune-mediated keratitis (IMMK) by use of in vivo confocal microscopy (IVCM) and/or histopathology. Unassigned: Medical records of horses presented to the Cornell University Equine Hospital definitively diagnosed with epithelial or stromal IMMK with IVCM and/or histopathology between 2020 and 2024 were reviewed. Patient signalment, affected eye(s), diagnostics, treatments, and outcomes were assessed. Unassigned: 22 horses met the inclusion criteria. The mean age was 16.9 years (SD, ...
Antiparasitic potential of Caesalpinia coriaria: Current evidence and prospects for equine health. Parasitic infections remain a major constraint to equine health and performance, and the worldwide rise of anthelmintic resistance is forcing a shift toward integrated parasite management and new complementary tools. Caesalpinia coriaria (Divi-divi) pods are exceptionally rich in tannins and have been proposed as a potential source of antiparasitic phytochemicals. This review summarizes the current evidence on C. coriaria, focusing on its relevance to equine gastrointestinal helminths. Most available data come from in vitro screening against ruminant nematode models (mainly Haemonchus contortu...
[Pigmentation disorders in the nasal vestibule of horses with nasal discharge]. The nasal vestibule of numerous horses is pigmented. In the ventral part of the nasal vestibule, this pigmentation is often disturbed resulting in a clearly depigmented area. As nasal discharge passes this area, our study aimed at the practical quantification of the depigmented area in the nasal vestibule of horses and the analysis of its relation to nasal discharge and other parameters.This study included 74 horses (59 warmblood horses, 15 ponies) with pigmented nasal vestibule. When a depigmentation was found to be present in the ventral part, this area was photographed and quantified by use...
Bridging Species with AI: A Cross-Species Deep Learning Model for Fracture Detection and Beyond. Fractures are a leading cause of morbidity and mortality in Thoroughbred racehorses, posing a significant threat to their welfare and careers. This study introduces a deep learning model specifically designed to facilitate fracture detection in equine athletes. By leveraging extensive training on human fracture data and refining the model with equine imaging, it highlights the transformative potential of transfer learning across species and medical contexts. This approach is not limited to equine fractures but could be adapted for use in detecting injuries or conditions in other veterinary spe...
Evaluation of Pulse Pressure as a Hemodynamic Marker of Cardiac Disease in Dogs and Horses Undergoing Pre-Anesthetic Assessment. Pulse pressure (PP) reflects ventricular stroke volume and arterial compliance, but its utility as a marker of cardiac disease in animals is not well established. This study evaluated the association between PP and echocardiographically confirmed cardiac abnormalities in dogs and horses and assessed its potential in pre-anesthetic evaluation. Clinical and echocardiography examination of 20 dogs and 20 horses was sufficient for inter-group comparisons and assignments to a Cardiac group (echocardiographically confirmed cardiac disease) or a Control group (healthy animals). Non-invasive oscillome...
Mental health challenges in the Irish thoroughbred horse breeding industry: Prevalence and associated risk factors. The thoroughbred horse breeding industry contributes significantly to the Irish economy. However, staff shortages threaten the economic sustainability of the industry, as well as the welfare of both horses and workers. Previous research on the staffing crisis faced by the broader horseracing industry has highlighted mental health concerns as a factor. Furthermore, the influence of workplace context on mental health has been widely recognised in organisational psychology. The aim of this study was to assess prevalence rates of Common Mental Disorders (CMDs) in Irish thoroughbred horse breeding ...
Comparative Evaluation of Follicular Flushing Frequency and Scraping Time During Ovum Pick-Up in Mares: Effects on Oocyte Recovery Rate and Technical Considerations. Transvaginal ultrasound-guided follicular aspiration or ovum pick-up (OPU) has become the standard technique for oocyte collection in mares for intracytoplasmic sperm injection (ICSI). Although repeated follicular flushes and wall scraping are commonly used to improve oocyte recovery rate (ORR), the relative contribution of each remains unclear. This study aimed to compare the effects of multiple flushes versus controlled scraping time on ORR in mares. A controlled trial was conducted in two phases: (1) an ex vivo phase using slaughterhouse ovaries (n = 32), and (2) an in vivo phase in c...
Thoroughbred Geldings’ Career: Influence of Age at the Start of Training and Racing. This retrospective report investigated whether starting racehorses' training and racing early is associated with a less successful and a shorter racing career. The data of 600 Thoroughbred racehorses from the German Racehorse Association's archiving programme were evaluated. The horses were classified into three groups regarding their different ages when starting training and racing: early training (16-24 months old)/early racing (two years old); early training/late racing (>two years old); and late training (25-30 months). Statistical models investigated effects on the horses' length of ca...
Diet composition influences equine large intestinal motility as measured by transcutaneous ultrasound. To quantify gastrointestinal motility at 3 anatomic locations of the large colon in healthy horses fed 2 diets. Unassigned: 12 American Quarter Horses were enrolled in a prospective crossover study. Horses received either a complete pelleted diet fed at 1.35% body weight (BW) per day or Coastal Bermudagrass hay fed at 2% BW with 0.5% to 0.7% BW of complete pelleted feed. Each diet was fed for 13 days prior to motility assessment. Two ultrasonographers recorded the frequency of contractions at the sternal flexure of the large colon, left ventral colon, and cecum for 4 consecutive, 1-minute peri...
Acquired and Degenerative Conditions of the Cervical Vertebral Column in Horses. The cervical vertebral column in horses plays a crucial role in movement, posture, and performance and disorders affecting it can cause pain, ataxia, or lameness. This review discusses major acquired (traumatic, infectious, neoplastic) and degenerative (osteoarthritis, foraminal stenosis, intervertebral disc disease) conditions. Acquired lesions often arise from trauma, bacterial infection, or neoplasia, with clinical signs ranging from neck pain to neurologic deficits. Degenerative disorders, particularly osteoarthritis of articular process joints, are common in the caudal cervical spine and ...
Blood and fecal metabolic responses of mature horses fed rhizoma peanut hay. Rhizoma peanut (RP, Arachis glabrata Benth) is an alternative legume forage to alfalfa (ALF, Medicago sativa L.) with less non-structural carbohydrates and crude protein. Yet, metabolic responses to consuming RP hay have never been evaluated in horses. Objective: The objective of this study was to investigate the effect of feeding RP 'Florigraze' hay on fecal and blood metabolic variables compared to alfalfa 'Legendary XHD' and bermudagrass (BMG, Cynodon dactylon L. 'Coastal') hays fed to maintenance horses. Methods: Six mature Quarter Horse geldings (596±40 kg) were randomly assigned to one ...
Sex-Related Differences in Show-Jumping Performance of Retired Thoroughbred Racehorses in Relation to the Interval Since Race Retirement. To investigate the factors affecting the utilization of retired Thoroughbred racehorses in equestrian disciplines, Bayesian linear mixed models were separately fitted using rank, round time, and obstacle faults from show-jumping competitions restricted to retired Thoroughbred racehorses as dependent variables, with the interaction between horse sex and the interval from race retirement to competition (as a proxy for transition training to show-jumping) as a fixed effect. When the interval was short (≤1 year), the estimated marginal mean of rank was statistically significantly lower in stalli...
Comparison of two doses of lidocaine constant rate infusion on cardiopulmonary function and recovery in isoflurane-anesthetized horses. To compare cardiopulmonary variables and recovery scores in isoflurane-anesthetized horses undergoing arthroscopy using two different intravenous (IV) lidocaine constant rate infusions (CRIs; 50 or 100 μg kg minute) under intermittent positive pressure ventilation (IPPV) or spontaneous ventilation (SV). Methods: Prospective, randomized, clinical study. Methods: A group of 30 client-owned horses, 8-156 months old (range), with body masses of 280-550 kg. Methods: Anesthesia protocol consisted of xylazine, ketamine and diazepam, and maintenance with isoflurane and a CRI of dexmedetomidine. All g...
Proteomic profiling of equine airway mucus reveals compositional changes in asthmatic phenotypes. Mucus hypersecretion and accumulation are hallmark features of equine asthma (EA), a meaningful respiratory disorder in horses occurring in mild to moderate (MEA) and severe (SEA) forms. Changes of the proteomic composition of airway mucus in EA are poorly understood. Using label-free quantitative liquid chromatography-mass spectrometry, we analyzed airway mucus from SEA (n = 10), MEA (n = 6), and healthy (n = 8) horses. We identified and quantified 2,275 proteins including gel-forming mucins MUC5AC and MUC5B and membrane-bound mucins MUC1 and MUC4. Compared with healthy controls, ...
Evaluation of computed tomographic anatomy of the foot in Jeju horses. Foot diseases are common causes of lameness in horses. Computed tomography (CT) is a valuable tool for diagnosing musculoskeletal lesions in horses and providing a detailed evaluation of foot diseases. Objective: The objective of this study was to establish reference ranges related to the feet of normal Jeju horses by measuring the angles and length of the hoof, and the Hounsfield Unit (HU) value of soft tissues in the foot. Methods: Sixteen normal Jeju horses (mean age: 4.25 years; mean body weight: 282.06 kg) without lameness were examined using CT. After CT scanning, the angles and lengths ...
Beyond the host: Unveiling the independent microbiome of equine gastrointestinal nematodes. Gastrointestinal nematode infections significantly impact equine health and welfare, with rising anthelmintic resistance demanding alternative control strategies. Emerging evidence suggests that parasitic nematodes harbour distinct microbiomes, potentially influencing host-parasite dynamics and parasite survival. This study aimed to characterize and compare the microbiomes of equine gastrointestinal nematodes and their hosts, focusing on differences in composition, diversity, and core microbiota structure across different intestinal sites, nematode subfamilies, and sexes. Faecal and nematode s...
Tissue-Engineered Osteochondral Allograft Versus Fresh Osteochondral Allograft: Comparable Cartilage and Subchondral Bone Repair in a 14-Month Equine Osteochondral Defect Model. Fresh osteochondral allograft (OCA) transplantation effectively repairs cartilage and subchondral bone; however, the persisting shortage of available donor OCAs and their short shelf-life make scheduling surgeries and meeting patient demand challenging. Attempts have been made to develop tissue-engineered solutions to address the limitations of OCA; nonetheless, these have failed to progress beyond the preclinical stage. Objective: To assess the safety and efficacy of a tissue-engineered osteochondral allograft (TE-OCA) as compared with equine OCA in an equine osteochondral defect model. Metho...
A novel oral immunotherapy strategy using transgenic barley induces Culicoides allergen-specific immune responses in horses. Insect bite hypersensitivity (IBH) is a seasonal, IgE-mediated allergic dermatitis of horses caused by salivary gland proteins of biting midges ( spp.). Current management relies on relief of clinical signs and on physical protection. In a previous pilot study, healthy horses were fed transgenic barley expressing a allergen via a special spiral bit, which successfully induced allergen-specific antibody responses. Building on this concept, the present study aimed to evaluate a more practical feeding approach, delivering transgenic barley expressing the major allergen Cul o 2p in a feed-compat...
Where Dinner Roams: The Role of Feral Horses as a Resource Subsidy for Wolves and Cougars in West-Central British Columbia. Feral horses () have established large populations in west-central British Columbia (BC), Canada, where they overlap with native ungulates, including a declining woodland caribou () herd. In addition, feral horses co-occur with large carnivore species including wolf () and cougar (). Feral horses may act as a resource subsidy for predators, potentially altering predator-prey dynamics, yet empirical observations of predator interactions with feral horses are scarce in Canada. Between 2019 and 2025, we documented 21 instances of wolf predation or scavenging of feral horses, including one direct ...
Advances in ELISA-based detection of equine leptospirosis. Leptospirosis is a globally distributed zoonosis that affects both humans and animals, with being the main causative agent. In horses, the disease is associated with considerable economic losses. The Microscopic Agglutination Test (MAT) is the reference test for diagnosis but has limitations, emphasizing the need for effective diagnostic alternatives. In this study, was evaluated the use of a recombinant chimera, composed of ErpY-like and LemA proteins, as an antigen for ELISA-based detection of equine leptospirosis. The chimera was successfully expressed, purified and tested on 915 horse ser...
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