Pratt-Phillips S.Obesity is an important health concern in horses, along with humans and companion animals. Adipose tissue is an inflammatory organ that alters the insulin-signaling cascade, ultimately causing insulin dysregulation and impaired glucose metabolism. These disruptions can increase the risk of metabolic disease and laminitis in horses and may also impact energy metabolism during exercise. A single bout of exercise, along with chronic exercise conditioning, increases insulin sensitivity and glucose disposal via both contraction- and insulin-mediated glucose uptake pathways. Regular exercise also in...
Potter SJ, Erdody ML, Bamford NJ, Knowles EJ, Menzies-Gow N, Morrison PK, Argo CM, McIntosh BJ, Kaufman K, Harris PA, Bailey SR.There is a high prevalence of obesity in ponies and pleasure horses. This may be associated with equine metabolic syndrome and an increased risk of laminitis. Body condition scoring (BCS) systems are widely used but are subjective and not very sensitive. Objectives: To derive a body condition index (BCI), based on objective morphometric measurements, that correlates with % body fat.
Forino S, Cameron L, Stones N, Freeman M.The ideal equestrian body image (BI) is a smaller physique and riders feel body shape (BS) influences subjective judge scoring within dressage competitions. The aims were to identify perceptions of equestrian coaches and dressage judges of rider body shape (BS), identify perceptions of appropriate horse-rider matching and establish the impact of BS on perceived rider ability. An online survey (GoogleFormsTM) was shared, respondents (n = 265, coaches = 174 judges = 91) viewed images of twelve riders of different BS (Ectomorph, Mesomorph, and Endomorph) mounted on three horses of different...
Pratt-Phillips S, Munjizun A.There is ample research describing the increased risk of health concerns associated with equine obesity, including insulin dysregulation and laminitis. For athletes, the negative effect of weight carriage is well documented in racing thoroughbreds (i.e., handicapping with weight) and rider weight has been shown to impact the workload of ridden horses and to some degree their gait and movement. In many groups of competitive and athletic horses and ponies, obesity is still relatively common. Therefore, these animals not only are at risk of metabolic disease, but also must perform at a higher wor...
Pratt-Phillips S, Munjizun A, Janicki K.Obesity is a critical problem in the equine industry, with ponies being at particularly high risk of developing obesity-related conditions such as metabolic syndrome and laminitis. The purpose of this study was to estimate the level of adiposity in an elite level of competitive show ponies, and to determine if adiposity was related to performance based on their model score (judged on conformation and appearance). Two researchers visually evaluated the body condition score (BCS) and cresty neck score (CNS) of 377 ponies at a national hunter competition. Thirty five percent of the ponies in the ...
Ishimaru M, Matsui A, Seki K, Korosue K, Akiyama K, Mizukami H, Yoshida T, Taya K.Changes in the body composition of 50 Thoroughbreds colts and fillies, born between 2004 and 2010, were compared between those reared at the Hidaka Training and Research Center (Hidaka), Hokkaido, which is extremely cold in winter, and those reared at the Miyazaki Yearling Training Farm (Miyazaki), Kyushu, which is mildly cold in winter. The horses were divided into two sex groups and reared and trained in Hidaka or Miyazaki for 7 months from October of one year of age to April of two years of age. Body weight (BW), rump fat thickness (RFT), fat-free mass (FFM), and percentage of fat (%F) were...
Busechian S, Turini L, Sgorbini M, Pieramati C, Pisello L, Orvieto S, Rueca F.Obesity and overconditioning are becoming more prevalent in horses, and are influencing the animal's health, activity, and reproductive efficiency. Body condition score (BCS) and cresty neck score (CNS) have been correlated with the development of various diseases. Many of the papers in the literature evaluate the prevalence of obesity and overconditioning in horse populations considering BCS given by owners. The aim of this study was to evaluate the validity of the owners' estimation of the degree of equine obesity or overconditioning by comparing BCS and CNS provided by each owner and a boar...
Iacono E, Lanci A, Gugole P, Merlo B.To use Mesenchymal Stromal Cells (MSCs) in equine patients, isolation and expansion are performed in a laboratory. Cells are then sent back to the veterinary clinic. The main goal of storage conditions during cell transport is to preserve their biological properties and viability. The aim of this study was to evaluate the effects of storage solutions, temperature and time on the characteristics of equine adipose tissue and Wharton's jelly-derived MSCs. We compared two different storage solutions (plasma and 0.9% NaCl), two different temperatures (4 °C and room temperature) and three time fram...
Nocera I, Bonelli F, Turini L, Madrigali A, Aliboni B, Sgorbini M.The body condition score (BCS) represents a practical but subjective method for assessing body fat reserves. Real time ultrasonography (RTU) has been proposed as an accurate method to objectively measure subcutaneous fat (SF) thickness and predict body fat reserves in cows, horses and donkeys. The aim of the present study was to describe RTU measures of SF thickness during periparturient period in jennies. The present prospective cohort study evaluated six dairy jennies. SF RTU were performed at 15 and 7 days before the presumptive delivery, and 2, 15 and 30 days after delivery. A portable ult...
Ahmadi F, Mirshahi A, Mohri M, Sardari K, Sharifi K.To investigate the hormonal and biochemical profiles of horses with osteochondrosis dissecans (OCD), serum insulin, cortisol, triiodothyronine, thyroxine, fasting blood glucose (FBG), cholesterol, triglyceride (TG), high- and low-density lipoproteins, albumin and uric acid were measured in horses definitely diagnosed with OCD (n=19) as well as clinically normal horses (n=18). Proxies representing insulin sensitivity [reciprocal of square root of insulin concentration (RISQI)] and beta cell responsiveness [modified insulin to glucose ratio (MIRG)] were calculated. Body fat percent (BF%) was est...
Walshe N, Cabrera-Rubio R, Collins R, Puggioni A, Gath V, Crispie F, Cotter PD, Brennan L, Mulcahy G, Duggan V.Obesity is endemic in human populations in the western society, and with mounting evidence that the intestinal ecological environment plays a major role in its pathogenesis, identification of therapies based on intestinal microbiota modulation are gaining attention. Obesity in companion animals is also a common clinical problem. We set out using a multidimensional approach, to determine the effectiveness and safety of a weight loss program for horses incorporating diet restriction and exercise. In addition, we aimed to investigate the effect of this program on the overall intestinal health of ...
Jansson A, Gunnarsson Vu00de, Ringmark S, Ragnarsson S, Su00f6derroos D, u00c1sgeirsson E, Ju00f3hannsdu00f3ttir TR, Liedberg C....This study examined the effect of altered body weight (BW) and body fat content on exercise performance and recovery. Nine horses were divided into two groups, and changes in BW and fat content were induced by feeding a high (HA) or restricted (RA) energy allowance for 36 days in a cross-over design. In the last week of each treatment, BW and body condition score (BCS) were recorded, body fat percentage was estimated using ultrasound, and a standardized incremental treadmill exercise test (SET) and competition-like field test were performed (scored by judges blinded to treatments). Blood samp...
Longland AC, Barfoot C, Harris PA.Obesity can negatively impact upon equine welfare and bodyweight (BW) of pastured equines is often difficult to manage. Objective: To compare the effects of three restricted grazing regimens on changes in pony BW and morphometric measurements. Methods: Randomised study. Methods: Twelve mature ponies were individually grazed in 10m wide, rectangular, electric fenced paddocks. The dry matter (DM) herbage yield of each paddock was determined, and paddock length adjusted on Day 1 to provide 1.5% of individual pony BW as herbage DM daily, for 28 days. There were four ponies per treatment. Treatmen...
Ribeiro RM, Ribeiro DS, Cota LO, Leme FO, M Carvalho A, Faleiros RR.This study aimed to characterize and correlate physiological and metabolic changes in horses fed a hypercaloric diet (HD). Nine mature horses with a mean initial body condition score of 2.9 ± 1 (scale, 1-9) were fed a high-calorie diet for 5 months. Fasting blood samples were collected before the study and biweekly for the duration of the project to determine the concentrations of cholesterol (CHOL), very low (VLDL), low (LDL) and high-density (HDL) lipoproteins, triglycerides, non-esterified fatty acids, and fructosamine. A low-dose oral glucose tolerance test (LGTT) was conducted before, 75...
Wallis N, Raffan E.Obesity is one of the most prevalent health conditions in humans and companion animals globally. It is associated with premature mortality, metabolic dysfunction, and multiple health conditions across species. Obesity is, therefore, of importance in the fields of medicine and veterinary medicine. The regulation of adiposity is a homeostatic process vulnerable to disruption by a multitude of genetic and environmental factors. It is well established that the heritability of obesity is high in humans and laboratory animals, with ample evidence that the same is true in companion animals. In this r...
Furtado T, Perkins E, Pinchbeck G, McGowan C, Watkins F, Christley R.Equine obesity is considered one of the most serious welfare concerns in UK leisure horses, yet little is known about how horse owners conceptualise their horse's weight as part of its health, or how they plan and carry out weight management. Objective: This study aimed to further our understanding of leisure horse owners' perceptions of equine health and awareness of excess fat in order to clarify our understanding of successful strategies for managing equine weight. Methods: This study used a qualitative research methodology. Methods: Data comprised 16 threads from online UK equine discussio...
Pizzi GLBL, Valente ALS, Rechsteiner SMEF, Bruhn FRP, Cruz LAX, Silva PM, Barbosa AA, Ribeiro PF, Martins CF.This study evaluated the influence of the Body Condition Score (BCS) and subcutaneous fat thickness on the tissue composition of the digital cushion in horses. Sixty mixed breeds of Criollo horses (21 males and 39 females) were sent for slaughter. All animals were submitted to BCS analysis, through visual antemortem evaluation, and then ultrasound evaluation to estimate the subcutaneous fat thickness. Macroscopic analyses of the thoracic and a pelvic limb (weight, volume, and density of the hooves and digital cushions) were performed. In addition, measurements of the area of internal structure...
Baker LA, Burrows AM, Nonella KJ, Pipkin JL, Holmes LD, McEvers TJ, Tennant TC, Tisdale ZM, Voyles AH, Lawrence TE.Relationships between live body condition score (BCS) and carcass fat depots have not been well established in equine. Our study was designed to quantify the relationship between BCS and fat depot measurements from equine carcasses. Live horses ( = 429) were evaluated immediately prior to immobilization at a commercial equine processor. Horses were independently assigned a BCS by a panel of three trained evaluators; BCS was evaluated by visual appraisal and manual palpation of the neck, withers, back, ribs, behind the shoulder, and tailhead. Median BCS frequencies were: 3.0 ( = 9), 4.0 ( = 43)...
Novello G, Segabinazzi LGTM, Lisboa FP, Canuto LE, Freitas-Dell'Aqua CP, Dell'Aqua JA, Canisso IF.This study compared the postthaw semen parameters of stallions with high and low body condition score (BCS) and evaluated associations between body morphometric parameters and postthaw semen parameters. Twenty stallions were split into Low BCS (BCS<7, n = 11) and High BCS (BCS ≥7, n = 9) groups, and underwent a complete morphometric analysis (e.g., neck scores and circumference, crest neck height, body weight, and height), and subcutaneous body fat thickness (SFT) at the tail head, withers, shoulders, and retroperitoneal space. A fasted oral sugar test (OST) was conducted on all stallio...
We compared the composition and content of fatty acids (FAs) in the liver, muscles, and subcutaneous fat of Yakut horses inhabiting extreme environment in the Cryolithozone. Essential linoleic and alpha-linolenic acids, supplied to horses with their food, were accumulated in different tissues. Linoleic acid was accumulated in the liver but alpha-linolenic acid was accumulated in muscle and subcutaneous fat. Such a distribution indicates different roles of these fatty acids in the metabolism of horses. Yakut horse meat is a valuable dietary product owing to its fatty acid composition and conten...
Williams CA, Kenny LB, Weinert JR, Sullivan K, Meyer W, Robson MG.The objective of this study was to determine whether rotational grazing generates horse, pasture, or cost benefits over continuous grazing. The study established two replicates (1.57 ha each) of rotational (R; four grazing sections and a stress lot per replicate, where horses were fed a moderate quality grass hay at 2% of body weight when not grazing) and continuous (C) grazing systems (treatments). Twelve Standardbred mares were grazed for an overall stocking rate of 0.52 ha/horse ( = 3 in each pasture). Recommended management practices for each grazing system were followed for 27 mo includin...
Valberg SJ, Borer Matsui AK, Firshman AM, Bookbinder L, Katzman SA, Finno CJ.Although muscle mass strongly influences performance, there is currently no effective means to measure the 3-dimensional muscle mass of horses. We evaluated a 3-dimensional (3D) scanning methodology for its ability to quantify torso and hindquarter volumes as a proxy for regional muscle mass in horses. Determine the repeatability of 3D scanning volume (V) measurements and their correlation to body weight, estimated body volume and muscle/fat ultrasound (US) depth. Handheld 3D photonic scans were performed on 16 Quarter Horses of known body weight 56 days apart (n = 32 scans) with each scan per...
Hill JA, Tyma JF, Hayes GM, Radcliffe R, Fubini SL.Obesity is common in the equine population and it has been associated with increased surgical morbidity and mortality in humans. The effect of increased body mass index (BMI) on the incidence of surgical site infections has not been investigated in horses. Objective: To determine whether horses with increased body fat, as estimated by BMI, are more likely to develop post-operative complications, particularly incisional complications, following emergency ventral midline celiotomy. Methods: Retrospective, multi-institutional clinical study. Methods: Medical records of horses >2 years old presen...
Jensen RB, Rockhold LL, Tauson AH.The main objectives of this study were to evaluate the accuracy of different body weight formulas for estimating body weight of Icelandic and Warmblood horses, as well as to assess the associations between the variables cresty neck score, body condition score, and plasma concentrations of leptin, insulin and cortisol. A total of 81 adult (≥ 4 years of age) horses (43 Icelandic and 38 Warmblood horses) was included in this study. The following morphological measurements were collected by two examiners simultaneously; body weight; height at withers; neck length; 0.5 neck length; neck circum...
Schroeder K, Van Allen J, Dhurandhar E, Lancaster B, Heidari Z, Cazenave K, Boone D, Erdman P.In this article, we present an exploratory case study that describes the initial outcomes of the Equine-Assisted Positively Fit (EAPF) program. Children with obesity and their caregivers were recruited to participate in the eight-session program. Results indicated that treatment completers ( = 2) had a decrease in fat mass and fat mass percentage and an increase in fat-free mass and fat-free mass percentage. Moreover, results from accelerometer measurements of physical activity indicated that participants increased their moderate to vigorous physical activity, as well as reported increased sel...
Fowler AL, Pyles MB, Bill VT, Hayes SH, Harris PA, Lawrence LM.Equine obesity is increasing in prevalence, and weight loss diets are frequently recommended for these horses. However, there are also management situations in which horses are deemed to be too thin. To monitor the efficacy of weight change programs, estimates of body fat are often made. There are several systems available to estimate body fat, and there are benefits and challenges to using each method. The objective of this study was to compare four different methods of estimating body fat in Thoroughbred horses. In 14 mature Thoroughbred horses, relationships among body condition score (BCS)...
He Y, Nadeau J, Reed S, Hoagland T, Bushmich S, Aborn S, Jones AK, Martin D.Our objective was to determine the influence of season (winter, spring, summer, and fall) on travel patterns, hoof growth, and longissimus dorsi muscle (LM) height and fat thickness between 13th and 14th ribs in 16 horses aged <4 years (eight males and eight females) of Morgan, Quarter Horse, and Moriesian breeds. Real-time ultrasound images of LM height and fat thickness as well as measures of hoof growth were obtained at the end of each season. Global positioning system tracking was conducted for four randomly selected days and one storm day in each season. Data were analyzed using a linear...
Girardi FM, da Fonseca LA, Ribeiro Filho JD, Souto PC, Ferreira DAC, Dornelas LRSM, Bento LD, de Carvalho Filho WP.Obesity in human and veterinary medicine is one of the most complex challenges within emerging diseases in the context of health. The problem of obesity in horses results in severe comorbidities; therefore, acute-phase proteins should be investigated for fluctuations increasing or decreasing by at least 25% in response to inflammation; these are candidates for future biomarkers and might provide new perspectives on early diagnosis and prognosis. Serum samples were analyzed in nine healthy animals (C) and nine obese animals (O). The proteins were separated by sodium dodecyl sulfate-polyacrylami...
Kearns CF, McKeever KH, Kumagai K, Abe T.This study examined whether body composition was predictive of competitive success in elite standardbreds (STB). Rump fat and muscle thickness (MTH) (vastus lateralis/intermedius [VL], extensor carpi radialis [ECR]) were measured in vivo in male n=6; female n=8 by B-mode ultrasound. Percentage body fat (%fat) was calculated from rump fat. There were no gender differences for age, body mass (males 432+/-11 kg; females 443+/-13 kg), fat-free mass (FFM) (males 400+/-12 kg; females 400+/-11 kg), ECR MTH (males 61+/-2 cm; females 60+/-2 cm) or race time (RT) (males 113+/-3 s; females 114+/-2 s). Ma...
Wallis N, Raffan E.Obesity is one of the most prevalent health conditions in humans and companion animals globally. It is associated with premature mortality, metabolic dysfunction, and multiple health conditions across species. Obesity is, therefore, of importance in the fields of medicine and veterinary medicine. The regulation of adiposity is a homeostatic process vulnerable to disruption by a multitude of genetic and environmental factors. It is well established that the heritability of obesity is high in humans and laboratory animals, with ample evidence that the same is true in companion animals. In this r...
Giles SL, Nicol CJ, Rands SA, Harris PA.Nuchal crest adiposity in horses and ponies has been associated with an enhanced risk of metabolic health problems. However, there is no current information on the prevalence of, and risk factors specific to, nuchal crest adiposity in horses and ponies. In addition, the cresty neck score has not previously been utilised across different seasons within a UK leisure population, it is not know whether nuchal crest adiposity shows the same seasonal trends as general obesity. Results: A Cresty Neck Score (CNS, 0-5) was given to 96 horses with access to pasture (>6 h per day) at the end of winte...
Bamford NJ, Potter SJ, Baskerville CL, Harris PA, Bailey SR.The importance of including exercise with dietary modification for the management of obese equids is not clearly understood. Objective: To evaluate the effect of a practical low-intensity exercise regimen, in addition to dietary restriction, on indices of insulin sensitivity (SI) and plasma adipokine concentrations in obese equids. Methods: Twenty-four obese (body condition score [BCS] ≥ 7/9) horses and ponies. Methods: Over a 12-week period, animals received either dietary restriction only (DIET) or dietary restriction plus low-intensity exercise (DIET+EX). All animals were provided wit...
De Palo P, Tateo A, Maggiolino A, Centoducati P.The present work describes the effect of nutritive level on horse carcass traits and on meat quality. Eighteen male Italian Heavy Draught Horse (IHDH) breed foals were employed in the study. Soon after foaling they were randomly subdivided into three groups according to three nutritive level classes: 150%, 180% and 200% of maintenance requirements. Live weight, hot carcass weight and dressing percentage of each animal were recorded. After slaughtering, meat samples were collected from Longissimus dorsi muscle. The right half carcass of each animal was then divided into cuts. Each one was subdi...
Remacha AR, Barrachina L, Álvarez-Arguedas S, Ranera B, Romero A, Vázquez FJ, Zaragoza P, Yañez R, Martín-Burriel I, Rodellar C.The immunomodulatory capacities of mesenchymal stem cells (MSCs) have made them the subject of increased clinical interest for tissue regeneration and repair. We have studied the immunomodulatory capacity of equine MSCs derived from bone marrow (BM-MSCs) and adipose tissue (AT-MSCs) in cocultures with allogeneic peripheral blood mononuclear cells (PBMCs). Different isoforms and concentrations of phytohaemaglutinin (PHA) were tested to determine the best stimulation conditions for PBMC proliferation and a proliferation assay was performed for 7 days to determine the optimal day of stimulation o...
de Laat MA, Hampson BA, Sillence MN, Pollitt CC.Obesity in horses is increasing in prevalence and can be associated with insulin insensitivity and laminitis. Current treatment strategies for obesity include dietary restriction and exercise. However, whether exercise alone is effective for decreasing body fat is uncertain. Objective: Our hypothesis was that twice daily use of a dynamic feeding system for 3 months would induce sustained, low-intensity exercise thereby decreasing adiposity and improving insulin sensitivity (SI). Methods: Eight, university-owned, mixed-breed, adult ponies with body condition scores (BCS) ≥5/9 were used. Metho...
Donaldson MT, LaMonte BH, Morresey P, Smith G, Beech J.Medical records of 27 horses (including 13 ponies) treated with pergolide or cyproheptadine for pituitary pars intermedia dysfunction were reviewed to determine the effect of treatment on plasma ACTH, insulin, and glucose concentrations and clinical signs. Prior to treatment, the most common clinical signs were laminitis, hirsutism, and abnormal body fat distribution. The median pergolide dose was 3.0 microg/kg p.o. q24h (range, 1.7-5.5 microg/kg). All horses treated with cyproheptadine were given 0.25 mg/kg p.o. q24h. After pergolide treatment, ACTH concentrations (n = 20; median = 30.4 pg/ml...
Dugdale AH, Curtis GC, Milne E, Harris PA, Argo CM.Excessive accumulations or depletions of body fat have been associated with increased morbidity and mortality in horses and ponies. An objective, minimally-invasive method to accurately quantify body fat in living animals is required to aid nutritional management and define welfare/performance limits. Objective: To compare deuterium oxide (D(2) O) dilution-derived estimates of total body water (TBW) and body fat with values obtained by 'gold standard' proximate analysis and cadaver dissection. Objective: D(2) O dilution offers a valid method for the determination of TBW and body fat in equids....
Kearns CF, McKeever KH, John-Alder H, Abe T, Brechue WF.It has long been known that body mass and, more specifically, lean body mass are strongly correlated with maximal oxygen uptake (VO2max) in man and animals. However, there are no data to date describing this phenomenon in the horse. The purpose of this paper is to examine the relationship between body composition and VO2max in the horse. Twenty-three healthy and unfit Standardbred mares performed an incremental exercise test (GXT) to measure VO2max. Rump fat thickness (RTH), a measure of fat covering, was measured using B-mode ultrasound. Plasma volume, total blood volume and red cell volume w...
Reynolds A, Keen JA, Fordham T, Morgan RA.Obesity is a common feature of equine metabolic syndrome (EMS). In other species, obese adipose tissue shows pathological features such as adipocyte hypertrophy, fibrosis, inflammation and impaired insulin signalling all of which contribute to whole body insulin dysregulation. Such adipose tissue dysfunction has not been investigated in horses. Objective: To determine if obese horses with EMS have adipose tissue dysfunction characterised by adipocyte hypertrophy, fibrosis, inflammation and altered insulin signalling. Methods: Cross-sectional post-mortem study. Methods: Samples of peri-renal (v...
Sessions-Bresnahan DR, Schauer KL, Heuberger AL, Carnevale EM.Obesity is associated with disrupted reproductive cycles in mares, but the impact of obesity on follicles and oocytes has received minimal attention. We investigated the impact of obesity on 1) expression of selected genes in follicle cells for carbohydrate metabolism, inflammatory cytokines, lipid homeostasis, endoplasmic reticulum stress, and mitochondrial function; 2) follicular fluid content of metabolic hormones and metabolites; and 3) lipid fingerprint of oocytes. Mares (9-13 yr) were classified as control (n = 8, normal weight, body condition score [BCS] 5.1, 10.4% body fat) or obese (n...
Webb AI, Weaver BM.Seventeen horses were dissected and their organs and tissues weighed. The results of these dissections are presented together with comparisons of the data with that already available in the literature. Predictive equations for organs and tissue weights are also given which were derived by comparison of linear and allometric regression models using 4 different body weight indices.
Castro FO, Torres A, Cabezas J, Rodríguez-Alvarez L.Repair of injured soft and hard tissues in horses can benefit greatly from the use of regenerative therapies with mesenchymal stem cells (MSC). Vitamin-C and platelet-rich-plasma had been used for in vitro differentiation of MSC. This study was aimed to evaluate the effect of vitamin-C, platelet-rich-plasma and their combination on the in vitro differentiation of adipose horse MSC. We isolated MSC from horse fat and differentiated them in vitro into osteogenic and chondrogenic lineages, as demonstrated by specific staining and RT-qPCR of selected genes. Combining vitamin-C and plasma-rich-plat...
Ralston SL.Abnormally high or low blood glucose and insulin concentrations after standardized glucose tolerance tests can reflect disorders such as pituitary dysfunction, polysaccharide storage myopathies, and other clinical disorders. Glucose and insulin responses, however, are modified by the diet to which the animal has adapted, time since it was last fed, and what it was fed. Body fat (obesity), fitness level, physiologic status, and stress also alter glucose and insulin metabolism. Therefore, it is important to consider these factors when evaluating glucose and insulin tests, especially if only one ...
Wooldridge AA, Edwards HG, Plaisance EP, Applegate R, Taylor DR, Taintor J, Zhong Q, Judd RL.To characterize adiponectin protein complexes in lean and obese horses. Methods: 26 lean horses and 18 obese horses. Procedures-Body condition score (BCS) and serum insulin activity were measured for each horse. Denaturing and native western blot analyses were used to evaluate adiponectin complexes in serum. A human ELISA kit was validated and used to quantify high-molecular weight (HMW) complexes. Correlations between variables were made, and HMW values were compared between groups. Results: Adiponectin was present as a multimer consisting of HMW (> 720-kDa), low-molecular weight (180-kDa)...
Gordon ME, McKeever KH, Betros CL, Manso Filho HC.Concentrations of hormones related to energy homeostasis may differ between populations with varied body compositions, acting as signals to increase or decrease energy intake and/or expenditure. How these parameters correlate with body composition in horses and how they vary in fit (F) versus unfit (UF) Standardbred racehorses is unclear. The purpose of this study was to test the hypothesis that plasma concentrations of glucose (GLU), insulin (INS), cortisol (CORT), ghrelin (GHRL), adiponectin (ADIP) and leptin (LEP) would be correlated with body composition and differ in fit (F) versus unfit ...
Dugdale AH, Curtis GC, Cripps PJ, Harris PA, Argo CM.Changes in appetite, body mass (BM), body condition score (BCS), direct (ultrasonographic) and indirect (deuterium oxide dilution technique) measures of body fat were monitored in Welsh Mountain pony mares (n=11, 5-19 years of age) offered ad libitum access to a complete diet (gross energy 16.9±0.07 MJ/kg dry matter) for 12 weeks during summer (n=6; 246±20 kg) and winter (n=5; 219±21 kg). At the outset, each group comprised two thin (BCS 1-3/9), moderate (BCS 4-6/9) and obese (BCS 7-9/9) animals. For ponies that were non-obese at the outset, BM was gained more rapidly (P=0.001) in summer (0...
Selim S, Elo K, Jaakkola S, Karikoski N, Boston R, Reilas T, Su00e4rkiju00e4rvi S, Saastamoinen M, Kokkonen T.Obesity and insulin resistance have been shown to be risk factors for laminitis in horses. The objective of the study was to determine the effect of changes in body condition during the grazing season on insulin resistance and the expression of genes associated with obesity and insulin resistance in subcutaneous adipose tissue (SAT). Sixteen Finnhorse mares were grazing either on cultivated high-yielding pasture (CG) or semi-natural grassland (NG) from the end of May to the beginning of September. Body measurements, intravenous glucose tolerance test (IVGTT), and neck and tailhead SAT gene exp...
Furtado T, Perkins E, Pinchbeck G, McGowan C, Watkins F, Christley R.Equine obesity is considered one of the most serious welfare concerns in UK leisure horses, yet little is known about how horse owners conceptualise their horse's weight as part of its health, or how they plan and carry out weight management. Objective: This study aimed to further our understanding of leisure horse owners' perceptions of equine health and awareness of excess fat in order to clarify our understanding of successful strategies for managing equine weight. Methods: This study used a qualitative research methodology. Methods: Data comprised 16 threads from online UK equine discussio...
Siegers EW, de Ruijter-Villani M, van Doorn DA, Stout TAE, Roelfsema E.Health risks associated with obesity are more likely a factor of the localization of fat excess, rather than of elevated BW per se. The aim of this randomized controlled clinical trial was to determine the effect of a long-term high energy diet on BW, fat accumulation and localization. Eight Shetland pony mares, 3 to 7 years old, were randomly divided into a control and a high energy (HE) diet group fed either maintenance or double maintenance energy requirements (200% net energy (NE)) for two consecutive summers, with a low energy diet in the winter in between. Body condition score (BCS) did ...
Wilson G, Chester N, Eubank M, Crighton B, Drust B, Morton JP, Close GL.Professional jockeys are unique among weight-making athletes, as they are often required to make weight daily and, in many cases, all year-round. Common methods employed by jockeys include dehydration, severe calorie restriction, and sporadic eating, all of which have adverse health effects. In contrast, this article outlines a structured diet and exercise plan, employed by a 22-yr-old professional National Hunt jockey in an attempt to reduce weight from 70.3 to 62.6 kg, that does not rely on any of the aforementioned techniques. Before the intervention, the client's typical daily energy intak...
Suagee JK, Corl BA, Wearn JG, Crisman MV, Hulver MW, Geor RJ, McCutcheon LJ.Obesity and insulin resistance increase the risk of laminitis in horses. Pioglitazone (PG) is an insulin-sensitizing drug used in humans that is absorbed after oral administration to horses. Objective: PG treatment will increase insulin sensitivity and transcript abundance of glucose and lipid transporters in adipose and skeletal muscle tissues. Methods: Sixteen lean, healthy horses. Methods: Eight horses were administered PG (1 mg/kg bodyweight PO) for 12 days before induction of insulin resistance through IV administration of lipopolysaccharide (LPS). Treated and untreated controls (CN; n = ...
Williams CA, Kenny LB, Weinert JR, Sullivan K, Meyer W, Robson MG.The objective of this study was to determine whether rotational grazing generates horse, pasture, or cost benefits over continuous grazing. The study established two replicates (1.57 ha each) of rotational (R; four grazing sections and a stress lot per replicate, where horses were fed a moderate quality grass hay at 2% of body weight when not grazing) and continuous (C) grazing systems (treatments). Twelve Standardbred mares were grazed for an overall stocking rate of 0.52 ha/horse ( = 3 in each pasture). Recommended management practices for each grazing system were followed for 27 mo includin...
Bruynsteen L, Janssens GP, Harris PA, Duchateau L, Valle E, Odetti P, Vandevelde K, Buyse J, Hesta M.The present study evaluated the effect of different levels of energy restriction on metabolic parameters in obese ponies. Relative weight changes, markers of lipid metabolism and oxidant/antioxidant balance were monitored. A total of eighteen obese (body condition score ≥ 7/9) Shetland ponies were studied over a 23·5-week trial, which was divided into three periods. The first period involved a 4-week adaptation period in which each animal was fed 100% of their maintenance energy requirements needed to maintain a stable obese body weight (MERob). This was followed by a 16·5-week weight-loss...
Fradinho MJ, Correia MJ, Gru00e1cio V, Bliebernicht M, Farrim A, Mateus L, Martin-Rosset W, Bessa RJ, Caldeira RM, Ferreira-Dias G.The aim of this study was to investigate the effects of body condition (BC), BC changes, and plasma leptin concentrations on the reproductive performance of Lusitano broodmares on extensive systems. Data from 119 mares (ranging from 4 to 22 years of age) were collected over a period of four consecutive breeding seasons. Each case was considered as one foaled mare bred in 1 year. Body condition changes at conception (ΔBCScon) showed a strong effect on fertility at the first two postpartum estrous cycles and a significant interaction with body condition score at conception (BCScon) was observed...
Martin-Gimenez T, de Blas I, Aguilera-Tejero E, Diez de Castro E, Aguirre-Pascasio CN.Equine metabolic syndrome (EMS) can be diagnosed by hormonal measurements; however, it would be important to find simpler measurements that allow easy identification of affected or at risk individuals. In horses, the dorsal neck region is one of the most frequent anatomical sites for fat deposition and neck obesity has been linked to EMS. The aim of this study was to evaluate the association of hormonal markers of obesity (leptin) and insulin resistance (insulin) with morphometric and ultrasonographic neck measurements in Andalusian horses. Plasma leptin and insulin concentrations were measure...
Cordero VV, Cavinder CA, Tedeschi LO, Sigler DH, Vogelsang MM, Arnold CE.Mathematical nutrition models have been developed for beef and dairy cattle to estimate dietary energy intake needed to change BCS. Similar technology has not been used to improve nutrition and feeding strategies for horses. An accurate equine nutrition model may enhance feeding management and reduce the costs of unnecessary overfeeding and promote an optimal level of fatness to achieve reproductive efficiency. The objectives of this study were to develop and evaluate a mathematical nutrition model capable of accurately predicting dietary energy changes to alter BW, rump fat (RF) thickness, an...
Heidler B, Aurich JE, Pohl W, Aurich C.This study summarizes weight development, plasma glucose concentrations and reproductive parameters in lactating (n = 46) and non-lactating Lipizzaner mares (n = 11) throughout the breeding season. It was the aim of the study to analyse if an energy deficit with possible effects on reproductive functions occurs at any time during the first 4 months of gestation. Mean gestation length was 334.3 +/- 7.3 days. Gestation of foals born in May/June was shorter (P < 0.01) than for foals born in March/April. Out of the 46 lactating mares, 44 ovulated between Days 8 and 18 postpartum and two mares o...
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