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Topic:Clinical Study
Clinical studies in equine research involve the systematic investigation of health and disease in horses through structured scientific methods. These studies aim to evaluate the safety and efficacy of treatments, understand disease mechanisms, and improve veterinary care practices. Clinical studies can include randomized controlled trials, observational studies, and case-control studies. They may focus on various aspects such as pharmacokinetics, therapeutic interventions, and diagnostic techniques. This page compiles peer-reviewed research studies and scholarly articles that explore the design, implementation, and findings of clinical studies in equine medicine, providing insights into their impact on horse health and veterinary practices.
Short-term effects of pulsed electromagnetic field therapy on subjective flexion-associated lameness responses and circulating cytokines in horses with distal tarsal osteoarthritis. Pulsed electromagnetic field (PEMF) therapy is commonly used in equine sports medicine for its proposed anti-inflammatory effects; however, limited controlled studies have evaluated its physiologic effects in horses. Objective: The objective of this study was to investigate the effects of PEMF therapy on flexion-induced lameness and circulating cytokines in horses with radiographic evidence of distal tarsal osteoarthritis. Methods: Six mares were enrolled in a repeated-measures crossover design in which each horse served as its own control. Horses were evaluated at baseline (sham PEMF) and at ...
Cryopreserved umbilical allograft (equicenta® CTM) improves clinical outcomes compared with clinician-selected standard of care in performance horses: a pragmatic prospective controlled trial. This multicenter, prospective, controlled clinical study and client survey evaluated the safety and effectiveness of an equine umbilical tissue suspension (equicenta® CTM; eCTM, 2:1) compared with clinician-selected standard of care (SOC) for treating lame performance horses. Unassigned: This pragmatic, real-world, open-label study enrolled horses diagnosed with appendicular musculoskeletal conditions affecting the joints, tendons, or ligaments under owner consent and an intention-to-treat design with an optional crossover after no improvement at 12 weeks and per-protocol analyses at 26 ...
Comparison of xylazine-ketamine-guaifenesin and xylazine-tiletamine-zolazepam protocols for constant rate infusion anesthesia in horses undergoing field castration. The common use of "triple drip" (xylazine, ketamine, and guaifenesin; XKG) is a popular protocol for constant rate infusion (CRI) in equine practice. However, due to restrictions on ketamine and guaifenesin in many countries, tiletamine-zolazepam (TZ) could serve as an alternative. To date, there have been limited studies evaluating the use of xylazine in combination with TZ (XTZ) administered via CRI to maintain surgical anesthesia in equine field practice. Objective: To compare the effectiveness and safety of XTZ infusion with the classical XKG protocol for field anesthesia. Methods: Twelve ...
Core decompression augmented with bone marrow aspirate concentrate for refractory distal sesamoid bone pathology in horses: A retrospective clinical study. To determine short- and long-term outcomes of core decompression combined with autologous bone marrow aspirate concentrate (BMAC) in treating moderate-to-severe refractory distal sesamoid bone (DSB) trabecular pathology in horses. Methods: Retrospective observational study. Methods: A total of 21 client-owned Warmblood horses with DSB pathology unresponsive to conservative management. Methods: Preoperative diagnosis included lameness localization by diagnostic analgesia and magnetic resonance imaging (MRI) confirmation of DSB trabecular pathology. Horses underwent arthroscopic core decompressi...
First Molecular Survey of Equine Adenovirus Type 1 Infection Among Horses in Poland. Equine adenovirus type 1 (EAdV-1) infection has been recognised among horses worldwide. The virus predominantly targets respiratory tract but has also been recovered from other body systems. The objective of the study was to determine the frequency of EAdV-1 infection among selected horse populations in Poland and to estimate genetic variability within the viruses obtained. A quantitative PCR assay targeting a partial gene was used to screen 1150 nasal swabs collected from 1145 horses from 19 horse studs throughout Poland. The samples were collected opportunistically between 2012 and 2025. A ...
Seasonal modulation of platelet indices in mares. Platelet indices provide valuable information on platelet activation, heterogeneity, and production kinetics, yet their physiological variability remains poorly characterized in horses. Although seasonal changes in platelet count have been described, the seasonal modulation of derived platelet indices in mares remains poorly understood. The aim of this study was to evaluate the seasonal variation of platelet count and derived platelet indices in clinically healthy mares from the Valencia region (Spain), and to assess their interrelationships. Forty clinically healthy Spanish Purebred mares (6-...
Retrospective endoscopic assessment of complications associated with nasogastric intubation in horses at a referral hospital. To characterize the incidence of complications confirmed via endoscopy following nasogastric intubation in horses at a referral institution and determine associated risk factors. Unassigned: Medical records of patients having received ≥ 1 nasogastric intubation within 3 days prior to endoscopic examination between March 2021 and March 2025 were identified. Signalment, history, clinicopathologic data, nasogastric intubation procedures, reason for endoscopy, treatment, and outcome were recorded. Complications were categorized by region (nasopharyngeal, esophageal, gastric). Clinical complicati...
Favorable survival of horses with guttural pouch mycosis following hospital-based treatment. To report the clinical outcomes and survival time in horses undergoing treatment of guttural pouch mycosis. Unassigned: Client-owned horses with guttural pouch mycosis admitted between 2005 and 2024 for evaluation and treatment were identified by medical record search. Signalment, disease history, and surgical and treatment details were recorded. Owners were contacted for follow-up information. Unassigned: 41 horses with guttural pouch mycosis were identified, of which 28 had epistaxis or a history of epistaxis on presentation. Thirty-five horses underwent surgical treatment, and the procedure...
Factors associated with equine influenza during the 2025 outbreak in a draft horse population at the Obihiro Racecourse, Japan. In April 2025, equine influenza re-emerged in Japan for the first time in 17 years, resulting in an outbreak at a horse racecourse for Ban'ei racing, a unique form of horse racing in which draft horses pull heavy sleds. This study aimed to describe the epidemiological characteristics of the outbreak and identify individual- and management-level factors associated with equine influenza cases in order to develop improved control programs. A retrospective analysis was conducted using clinical records reported to the racecourse authority between April 21 and June 18, 2025. Cases were defined based...
Effect of neonatal rib fracture repair on racing and sales performance in Thoroughbreds. The racing outcome of horses that have undergone surgical repair of neonatal rib fractures is not well documented. Objective: To evaluate the impact of surgical repair of neonatal rib fractures on subsequent sales and racing performance in Thoroughbreds. Methods: Retrospective cohort study. Methods: Medical records of neonatal Thoroughbreds that underwent surgical repair of rib fractures at a referral hospital between 2014 and 2025 were reviewed. Sales and racing data were obtained from publicly available databases. Outcomes assessed included sale price at weanling and yearling sales, total ca...
Oxidative Stress and Immunomarkers in Equine Dermal Melanomatosis: Single-Case Comparison with Healthy Individual. Dermal melanomatosis is a common tumor in grey horses, characterized by cutaneous/subcutaneous lesions with metastatic potential. While clinically well-described, oxidative stress involvement remains poorly understood. This case report compared oxidative stress markers and antioxidant enzymes' activities in total protein extracts from melanomatosis lesions (grey horse) versus healthy control skin (black horse), alongside histopathology and immunohistochemistry, to correlate oxidative imbalance and tumor behavior. Melanomatosis tissue exhibited decreased antioxidant defenses confirmed by catala...
Ceratohyoidectomy for Management of Unilateral and Bilateral Temporohyoid Osteoarthropathy: Long-Term Outcome in 33 Equids. Temporohyoid osteoarthropathy is a disease affecting the temporohyoid joint in equids caused by local inflammation and/or degeneration, leading to neurological deficits ranging from mild signs that affect performance to significant, acute neurological deficits such as facial nerve paralysis or vestibular signs. Multiple surgical treatment options are available, and while treatment has historically been performed unilaterally on the side of the clinical signs, advances in diagnostic imaging have highlighted the occurrence of bilateral disease of the temporohyoid joints, warranting evaluation of...
Perineural dexamethasone does not prolong bupivacaine sensory blockade in equine palmar digital nerve blocks: a randomized crossover trial. To determine whether dexamethasone sodium phosphate (dexamethasone SP) prolongs the sensory blockade produced by perineural bupivacaine during medial and lateral palmar digital nerve blocks in horses. Unassigned: 8 healthy adult horses were enrolled in a blinded, randomized 4 X 4 crossover trial. Each horse received 1 of 4 perineural treatments over the palmar digital nerves of the left forelimb: bupivacaine, bupivacaine + dexamethasone SP, dexamethasone SP alone, or saline. A minimum 7-day washout was used between treatments. Mechanical nociceptive threshold (MNT) was measured at baseline and...
Efficiency of transvaginal oocyte aspiration (TVA), post-mortem ovary harvest (OH), and Intracytoplasmic Sperm Injection (ICSI) in a Quarter Horse mare population in North America. In a clinical setting, Intracytoplasmic Sperm Injection (ICSI)-derived equine blastocysts can be obtained either by transvaginal oocyte aspiration (TVA) or post-mortem ovary harvest (OH). Most peer-reviewed retrospective reports have described the suitability of these techniques for obtaining blastocysts, pregnancies, and live foals, particularly in Warmblood horse populations in Europe. In this study, retrospective data from Quarter Horse client-owned mares subjected to TVA-ICSI (n = 105; 151 cycles) or OH-ICSI (n = 42) at an academic institution in North America between 2023 and 2025...
Effects of TECAR Therapy on Body Surface Temperature and Longissimus Dorsi Muscle Tone in Thoroughbred Racehorses: A Pilot Study. Capacitive and resistive electric transfer (TECAR) therapy is increasingly used in equine physiotherapy; however, objective evidence regarding its immediate effects on equine back muscles remains limited. This pilot study aimed to evaluate the effects of TECAR therapy on body surface temperature and muscle tone of the longissimus dorsi muscle in Thoroughbred racehorses. A randomized, single-blinded experimental study was conducted in 20 clinically healthy Thoroughbred racehorses aged 2-3 years. Horses were randomly assigned to either a TECAR treatment group ( = 10) or a sham-treatment control ...
An observational study evaluating the environmental impact of equine arthroscopy. Human pressures on Earth's life‒support systems have exceeded multiple planetary boundaries, highlighting the need for sectors, including veterinary healthcare, to reduce environmental impacts. Methods: A prospective convenience sample of 10 horses undergoing arthroscopy at a UK equine hospital between January and March 2025 was studied. Data were collected on anaesthesia, volatile capture, pharmaceuticals, single-use consumables, waste, building energy and travel by horses and staff. Carbon emissions (kgCOe) were calculated using published conversion factors. A hybrid methodology combined b...
Effect of lingual gauze swab placement and light exclusion on pulse oximeter agreement with arterial haemoglobin-oxygen saturation derived from blood-gas analysis in healthy anaesthetised horses. To compare peripheral arterial haemoglobin-oxygen saturation values obtained using pulse oximetry (SpO) with and without a lingual gauze swab under ambient light and light-exclusion conditions, with arterial haemoglobin-oxygen saturation derived from arterial blood-gas analysis (SaO). Methods: Prospective method-comparison study. Methods: A group of 60 healthy adult horses undergoing elective general anaesthesia. Methods: In American Society of Anesthesiologists (ASA) physical status classification I-II horses, SpO readings were obtained under six conditions during anaesthesia: no swab, no swa...
Intratumoral para-toluenesulfonamide as a tumor-ablative therapy for equine cutaneous tumors: a case series of three horses. Equine neoplasia, including sarcoids, melanomas, and squamous cell carcinomas, presents therapeutic challenges due to recurrence and limitations of conventional treatments. Para-toluenesulfonamide (p-TLS) is a tumor-ablating agent that is associated with localized tumor necrosis and subsequent lesion resolution. It has been evaluated in human clinical settings as an intratumoral treatment of malignant airway obstruction caused by non-small cell lung cancer. This study aimed to describe the clinical outcomes and tolerability of intratumoral p-TLS in equine neoplasia. Three equine cases, includi...
Limited Effects of High-Intensity Laser Therapy on Clinical and Radiographic Outcomes in Three-Year-Old Arabian Racehorses with Dorsal Metacarpal Disease. Dorsal metacarpal disease (DMD) is a common musculoskeletal injury in young racehorses, and effective non-invasive treatments remain of clinical interest. This study aimed to evaluate whether high-intensity laser therapy (HILT), which was applied as the sole intervention in horses retired from training, reduces the clinical signs of DMD compared with untreated controls. During the 2023-2024 racing seasons, 15 Arabian racehorses diagnosed with DMD were enrolled; 9 received HILT and 6 served as controls without laser therapy. The treatment protocol consisted of five daily HILT sessions followed ...
Electrochemotherapy Following Surgical Cytoreduction for the Treatment of Recurrent Equine Sarcoids: A Retrospective Study of 23 Lesions. Despite the wide range of therapeutic options currently available for equine sarcoids, recurrence of these lesions remains a major clinical challenge. Consequently, the identification of effective strategies for the management of recurrent sarcoids remains an important objective in equine oncology. The aim of this retrospective study was to evaluate the clinical outcome of surgical cytoreduction combined with intraoperative electrochemotherapy in horses affected by recurrent equine sarcoids. Medical records of horses treated between July 2018 and August 2025 at the Veterinary Teaching Hospital...
Isolation of high-quality stallion spermatozoa: a comparison of methods and their effects on sperm quality and yield, DNA damage, and functional competence by ICSI. Intracytoplasmic sperm injection (ICSI) is the primary method for equine in vitro embryo production, yet outcomes may be influenced by sperm selection techniques. Objective: This study compared four isolation methods: EquiPure™, Vetmotl™, Felix™, and Samson™, to assess effects on sperm quality and embryo development. Methods: Semen was collected from four fertile stallions, processed and evaluated for sperm motility, viability, DNA integrity, and yield of high-quality cells relative to input. Isolated samples were compared to non-isolated (centrifuged) samples. Spermatozoa were used fo...
Improving concussion assessment in jockeys: normative benchmarks and web-based tool for ImPACT interpretation. Despite horse racing's exceptionally high concussion risk, there is no jockey-specific ImPACT study. This work aimed to develop demographically adjusted, jockey-specific ImPACT norms and to evaluate complementary approaches to clinical classification. Unassigned: Retrospective baseline data from 663 Irish jockeys (2021-2024) were analyzed. Two normative methods were applied: (i) a univariate regression-based approach estimating expected scores for each cognitive domain independently, adjusting for age, sex, and education, with percentile-based classification; and (ii) a multivariate regression...
Plasma and Urinary Concentrations of Synephrine in Horses Following Controlled Oral Administration. Synephrine is a sympathomimetic alkaloid of regulatory interest in both horse racing and equestrian sports, where feed‑related exposure may lead to its detection in equine blood and urine. This study characterized plasma and urinary concentrations of synephrine in horses following controlled oral administration. Six Thoroughbred horses received single oral doses of 100 mg or 800 mg synephrine, and blood and urine samples were collected sequentially. Each sample was analyzed both before and after β‑glucuronidase hydrolysis, demonstrating that synephrine was present predominantly as conjuga...
The Role of Artificial Intelligence in Equine Colic: A Scoping Review of Diagnostic, Prognostic, and Decision-Support Applications. Equine colic remains one of the leading causes of mortality in horses, with timely diagnosis and accurate prognostic assessment being critical for clinical decision-making. In recent years, artificial intelligence (AI) has been increasingly applied to support diagnostic and prognostic evaluation in veterinary medicine. However, the scope, methodological characteristics, and performance of AI models in equine colic have not been systematically mapped. Therefore, this scoping review was conducted to summarize current AI applications in equine colic, identify commonly used algorithms, describe re...
Clinical and microbiota alterations in performance horses undergoing long-distance transport. Transport-associated pneumonia contributes substantially to morbidity, impaired welfare, and economic loss in high-performance horses and may be associated with alterations in the respiratory microbiota. Objective: Examine the effect of long-distance transport on the respiratory microbiota and correlate changes in microbiota diversity and composition with systemic and airway inflammation. Methods: Seventeen client-owned performance horses transported from New England to Florida under optimized trailering conditions, and 12 non-traveling horses. Methods: Physical examination, blood testing, nas...
Correlation of Positron Emission Tomography and Low-Field Standing Magnetic Resonance Imaging in Horses With Forelimb Lameness Localized to the Foot. Low-field magnetic resonance imaging (LF-MRI) and positron emission tomography (PET) imaging can be obtained in the standing horse. There is potential for increased diagnostic capacity combining PET with MRI, given that PET assesses the metabolic activity of injured tissues, whereas MRI provides structural and functional details on both bone and soft tissue anatomy. This study aimed to describe 18-fluorine-fluorodeoxyglucose (F-FDG)-PET and 18-sodium fluoride (F-NaF)-PET imaging of horses with forelimb lameness localized to the foot and compare PET with LF-MRI. Fourteen horses with lameness lo...
Preliminary investigation of ghrelin in horses and ponies: receptor expression and associations with prandial state, morphometry and signalment. The hormone ghrelin has had limited attention in Equidae, despite connections with appetite and metabolic health in other species. Ghrelin influences hunger and food intake, energy expenditure and storage, glucose metabolism, and thermoregulation, through its receptor-mediated effects on tissues and via interaction with other hormones. There are two circulating forms, acylated and des-acylated ghrelin, considered to have distinct effects on metabolism in other species. The aims of this study were to confirm the presence of ghrelin receptors in equine tissues, to validate an assay for the measu...
Reply to Henshall et al. Commentary on “MacKechnie-Guire et al. Measuring Noseband Tightness on the Lateral Aspect of the Horse’s Face. Animals 2025, 15, 537”. In a paper published in 2017, Doherty et al [...].
Parents’ perspectives on equine-assisted occupational therapy intervention for their children with attention deficit hyperactivity disorder (ADHD). This study examined how parents experienced the ASTride Equine-Assisted Occupational Therapy intervention for their children with ADHD, and the meanings they ascribed to changes observed in their children and themselves. Unassigned: Thirteen parents of children aged 7-12 who completed the ASTride intervention participated in in-depth, semi-structured interviews. A grounded theory approach guided the analysis, which included open coding, category mapping, and thematic modeling to identify central processes across narratives. Unassigned: (1) Parents' perceived benefits for children including emo...
